Paper
Local structural flexibility drives oligomorphism in computationally designed protein assemblies
This study uncovers how subunit flexibility in computationally designed protein assemblies leads to unexpected but defined structural diversity, suggesting that incorporating controlled flexibility can enhance the design of dynamic and functional protein nanostructures.
Product Tag:
Protein
Industry Tag:
Synthetic Biology
Esophageal Reconstruction with Myogenesis-Inducing Gene Transfected Mesenchymal Stem Cell-Seeded Film with Leaf-Stacked Structure
This study evaluates tissue-engineered films (FLSS) seeded with mesenchymal stem cells (MSCs) genetically modified with myogenic genes for esophageal reconstruction. Results show that FLSS with myogenesis-inducing gene-transfected MSCs enhances smooth muscle regeneration and epithelial repair, offering potential for functional esophageal regeneration.
Dual-Mode RPA/CRISPR-Cas12a Biosensor Based on Silica and Magnetic Hybrid Nanobeads for Rapid Detection of Campylobacter jejuni
This study presents a dual-mode biosensor combining RPA, CRISPR/Cas12a, and a nanozyme for highly sensitive and selective fluorometric and colorimetric detection of Campylobacter DNA, with successful application in raw food analysis.
Marine Metagenome Mining Reveals Lanthipeptides Colwesin A–C, Exhibiting Novel Ring Topology and Anti-inflammatory Activity
This study reports the discovery and structural characterization of three novel lanthipeptides, colwesins A–C, from Colwellia_A sp., showcasing unique thioether ring topologies and anti-inflammatory activity, expanding the structural and functional diversity of marine-derived natural products.
Development of a Transposon-Based Genome Engineering Toolkit for Efficient and Adaptable Genetic Modifications in Wolfiporia cocos
This study introduces a transposon-based genome engineering toolkit tailored for Wolfiporia cocos, enabling efficient, multiplexed gene integration and stable expression, thereby advancing synthetic biology applications in fungal biotechnology.
Redesigning CYP109E1 for Improving Catalytic Performance in 25-Hydroxyvitamin D3 Synthesis Through Synergistic Enhancement of Electron Transfer and NADPH Regeneration
This study demonstrates the optimization of CYP109E1 from Bacillus megaterium for enhanced 25(OH)VD3 production by engineering a strain with improved redox partners and an NADPH regeneration system, resulting in a 48.7% increase in yield.
Engineering the Specificity of Acetyl-CoA Synthetase for Diverse Acyl-CoA Thioester Generation
This study explores the engineering of an acyl-CoA ligase from Pseudomonas chlororaphis to enhance its activity with a diverse range of carboxylic acids, enabling the biosynthesis of diversified pyrones and advancing natural product scaffold diversification.
Product Tag:
Enzyme
Industry Tag:
Synthetic Biology
Reconstitution and Characterization of Biosynthetic Machinery for Parageocin I, a Novel Thiazole-Rich Peptide from the Thermophilic Bacterium Parageobacillus caldoxylosilyticus
This study characterizes the biosynthesis of parageocin I, a novel thiazole-rich linear azol(in)e-containing peptide (LAP) from Parageobacillus caldoxylosilyticus, providing insights into LAP biosynthesis and expanding knowledge on secondary metabolism in thermophilic bacteria.
Product Tag:
Parageocin
Industry Tag:
Synthetic Biology
Industry leaders use Knowledge Hub to explore 418+ Synthetic Biology Papers
Gain unparalleled insights, and drive your breakthrough forward.
Let’s shape tomorrow, today!