ACCELERATING. SYNTHETIC BIOLOGY. ADVANCEMENT

Revive & Restore received a $2 million grant from the Bezos Earth Fund to develop AI tools that automate the final stages of genome assembly, significantly speeding up the decoding of complete genetic blueprints for endangered species.

Ansa Biotechnologies launched its 50 kb Clonal DNA product, the longest sequence-perfect synthetic DNA commercially available, enabling researchers to obtain fully verified, error-free DNA constructs within 25 days through its proprietary enzymatic synthesis platform backed by an on-time delivery guarantee.

Arcturus Therapeutics released interim Phase 2 results for its inhaled mRNA therapeutic, ARCT?032, in adults with class I Cystic Fibrosis receiving daily 10 mg doses over 28 days.The treatment was generally well-tolerated, and imaging data showed reduction in mucus plugs/volume in 4 of 6 participants, though meaningful improvements in lung function (FEV?) were not achieved in this short-term cohort.

Integrated DNA Technologies (IDT) and Profluent Bio have launched a strategic collaboration combining Profluent’s generative AI platform for protein design with IDT’s genomics and enzyme-engineering expertise. The partnership aims to accelerate the development of new next-generation enzyme variants with broad applications in synthetic biology, gene editing, and beyond.

Recombinant humanized type III collagen with a triple-helix structure, built from low-immunogenic, high-activity fragments, is efficiently expressed in engineered bacteria at high yield.

A freckle-removing composition with recombinant humanized collagen linked between two functional fragments of type III collagen and histidine, providing low-irritation skin whitening.

Recombinant type VII collagen with 2–100 repeats of GLPGAKGEKGAP, expressed in Pichia pastoris with up to 17.3 g/L yield, enhances autophagy and delivers anti-wrinkle effects.

Recombinant type III collagen, engineered from the human ?1 strand gene and produced in Pichia pastoris offers higher yield for skin regeneration and repair.

Researchers developed a collagen-like protein, S1552, that is directed into the periplasm of E. coli, where it strengthens the cell barrier and improves resistance to stressors like salt, pH extremes, antibiotics, and heavy metals, with potential use in other bacteria

The study introduces antisense RNA (asRNA)-mediated sequestration as a novel mechanism to improve inverting genetic logic gates by co-expressing asRNAs with mRNAs to enhance repression through additional feedback, thereby steepening dose–response curves, reducing OFF-state leakage, and enabling tunable logic transitions for constructing robust combinational circuits; results: improved gate sharpness and reduced leakage.

This study presents an automated one-step multigene assembly method that leverages optimized in vivo homologous recombination within a shuttle vector to efficiently construct expression-tunable multigene libraries, with the process miniaturized for high-throughput applications, successfully enabling rapid and parallel gene assembly in a biofoundry setting.

This study introduces the Array Assembler, a user-friendly computational tool that streamlines the design of oligonucleotides for assembling large crRNA arrays from user-defined spacer sequences, addressing the complexity and error risks in multitarget CRISPR experiments and enabling rapid, reliable construction of crRNA arrays for diverse genomic perturbation applications.