ACCELERATING. SYNTHETIC BIOLOGY. ADVANCEMENT

Form Bio partnered with Weill Cornell Medicine to apply AI-driven vector design and gene editing for developing therapies that lower Alzheimer’s disease risk in patients with high-risk genetic variants, marking the first phase of a multi-step clinical translation program.

The University of Liverpool and CyanoCapture Ltd partnered to develop carboxysome-based targeted drug delivery systems by combining cyano­bacteria engineering, peptide expression, and CRISPR-based molecular tools with scalable biomanufacturing to create protein nanocage platforms for biopharmaceutical applications.

Fork & Good acquired Orbillion Bio to combine their cultivated meat operations and accelerate the global commercialization of their red meat protein platform.

Samsung Ventures invested in Arbor Biotechnologies to support the development of next-generation in vivo gene editing therapies for genetic diseases of the liver and central nervous system, reinforcing Samsung’s commitment to advancing biopharmaceutical technologies with meaningful clinical impact.

Recombinant humanized type III collagen with a triple-helix structure, built from low-immunogenic, high-activity fragments, is efficiently expressed in engineered bacteria at high yield.

A freckle-removing composition with recombinant humanized collagen linked between two functional fragments of type III collagen and histidine, providing low-irritation skin whitening.

Recombinant type VII collagen with 2–100 repeats of GLPGAKGEKGAP, expressed in Pichia pastoris with up to 17.3 g/L yield, enhances autophagy and delivers anti-wrinkle effects.

Recombinant type III collagen, engineered from the human ?1 strand gene and produced in Pichia pastoris offers higher yield for skin regeneration and repair.

Researchers developed a collagen-like protein, S1552, that is directed into the periplasm of E. coli, where it strengthens the cell barrier and improves resistance to stressors like salt, pH extremes, antibiotics, and heavy metals, with potential use in other bacteria

The study introduces antisense RNA (asRNA)-mediated sequestration as a novel mechanism to improve inverting genetic logic gates by co-expressing asRNAs with mRNAs to enhance repression through additional feedback, thereby steepening dose–response curves, reducing OFF-state leakage, and enabling tunable logic transitions for constructing robust combinational circuits; results: improved gate sharpness and reduced leakage.

This study presents an automated one-step multigene assembly method that leverages optimized in vivo homologous recombination within a shuttle vector to efficiently construct expression-tunable multigene libraries, with the process miniaturized for high-throughput applications, successfully enabling rapid and parallel gene assembly in a biofoundry setting.

This study introduces the Array Assembler, a user-friendly computational tool that streamlines the design of oligonucleotides for assembling large crRNA arrays from user-defined spacer sequences, addressing the complexity and error risks in multitarget CRISPR experiments and enabling rapid, reliable construction of crRNA arrays for diverse genomic perturbation applications.