ACCELERATING. SYNTHETIC BIOLOGY. ADVANCEMENT

Grove Biopharma raises $30 million in Series A funding, led by DCVC Bio and joined by Eli Lilly, to further develop its Bionic Biologics™ platform targeting intracellular disease.

ZymoChem announces the successful commercial-scale production of a key biopolymer for BAYSE™, the world’s first scalable, bio-based, microplastic-free, and biodegradable Super Absorbent Polymer.

The company has unveiled a new brand identity, Cosaic, alongside the introduction of Cosaic Neo, a next-generation ingredient developed through advanced yeast biotechnology.

South Korea has passed a pioneering law to institutionalize support for synthetic biology. The act includes a national biofoundry, funding plans, and a five-year strategy, aiming to strengthen Korea's position in the fast-growing $3.6 trillion global biotech market.

The invention presents a polyphosphokinase mutant designed to improve the efficiency of the ATP regeneration system. By introducing mutations Y286Stop or L290Stop in the wild-type polyphosphokinase, the mutant exhibits higher activity. When used in a genetically engineered Escherichia coli strain, this mutant catalyzes the synthesis of NMN (nicotinamide mononucleotide) from D-ribose, ATP, and nicotinamide, achieving a high yield of 25.2 g/L in 3 hours, demonstrating significant industrial potential for large-scale NMN production.

The invention provides a method for producing polyhydroxyalkanoate (PHA) via semi-continuous fermentation using Halomonas as a base strain, with the overexpression of the cell division protein gene ftsZ. This approach addresses the issues of reduced splitting activity and lower yield due to metabolic disturbances during long continuous fermentation, achieving high PHA yields in practical applications, and offering strong potential for industrial scalability.

The invention discloses a pectinase-producing strain, identified as Microvesicles MYHB-202306PeC, belonging to the Microvesicles genus. This strain is capable of high salt tolerance and the secretion of pectinase, which makes it useful in applications such as food processing, waste management, and other industrial uses requiring pectin degradation.

The invention discloses a kind of sea source bacteria secreting xylanase and its application, and relates to the field of microbial technology, and the invention discovers a new microbial strain, and the bacteria are identified and confirmed to belong to the genus sea source bacteria, named as sea source bacteria MYHB-202307XyL (Aliidiomarina sp. MYHB-202307 XyL). Experiments prove that the strain has the capability of resisting high salt and secreting xylanase.

This study uncovers how subunit flexibility in computationally designed protein assemblies leads to unexpected but defined structural diversity, suggesting that incorporating controlled flexibility can enhance the design of dynamic and functional protein nanostructures.

This study evaluates tissue-engineered films (FLSS) seeded with mesenchymal stem cells (MSCs) genetically modified with myogenic genes for esophageal reconstruction. Results show that FLSS with myogenesis-inducing gene-transfected MSCs enhances smooth muscle regeneration and epithelial repair, offering potential for functional esophageal regeneration.

This study presents a dual-mode biosensor combining RPA, CRISPR/Cas12a, and a nanozyme for highly sensitive and selective fluorometric and colorimetric detection of Campylobacter DNA, with successful application in raw food analysis.

This study reports the discovery and structural characterization of three novel lanthipeptides, colwesins A–C, from Colwellia_A sp., showcasing unique thioether ring topologies and anti-inflammatory activity, expanding the structural and functional diversity of marine-derived natural products.