LATEST RESEARCH

LATEST HUB NEWS

WuXi AppTec Launches NMR-Based FBDD Platform for Drug Discovery

WuXi AppTec introduces a customizable NMR-based fragment screening platform with 4K+ fragment library, orthogonal validation methods, and SAR-driven structural modeling to accelerate drug design.

2 weeks ago Product Launch

British Scientists Create Syn57: E. coli with Radically Recoded Genome

Researchers at MRC Laboratory of Molecular Biology engineered Syn57 with only 57 codons after 100,000 DNA edits, unlocking potential for novel amino acids and virus-resistant bacteria.

2 weeks ago Technology Development

WashU Receives $5.2M for Advanced Biomanufacturing Research

Washington University researchers, led by Prof. Fuzhong Zhang, will develop a genetic “switch” enabling microbes to sustain high-efficiency continuous fermentation, funded with up to $5.2 million from DARPA.

2 weeks ago Investment

Colorcon Ventures Invests in Phytolon to Advance Natural Colors via Precision Fermentation

Phytolon receives strategic investment to commercialize natural, high-performing colors via precision fermentation, aligning with Colorcon’s commitment to innovation and sustainable solutions.

2 weeks ago Investment

LATEST HUB PATENTS

Alcohol dehydrogenase mutant and application thereof in preparation of high-concentration (S)-glassine.

The invention presents a polyphosphokinase mutant designed to improve the efficiency of the ATP regeneration system. By introducing mutations Y286Stop or L290Stop in the wild-type polyphosphokinase, the mutant exhibits higher activity. When used in a genetically engineered Escherichia coli strain, this mutant catalyzes the synthesis of NMN (nicotinamide mononucleotide) from D-ribose, ATP, and nicotinamide, achieving a high yield of 25.2 g/L in 3 hours, demonstrating significant industrial potential for large-scale NMN production.

11 months ago

Synthetic Biology

Method for producing PHA through semi-continuous fermentation

The invention provides a method for producing polyhydroxyalkanoate (PHA) via semi-continuous fermentation using Halomonas as a base strain, with the overexpression of the cell division protein gene ftsZ. This approach addresses the issues of reduced splitting activity and lower yield due to metabolic disturbances during long continuous fermentation, achieving high PHA yields in practical applications, and offering strong potential for industrial scalability.

1 year ago

Packaging

Material

Pectase-producing microbubble bacteria and application thereof.

The invention discloses a pectinase-producing strain, identified as Microvesicles MYHB-202306PeC, belonging to the Microvesicles genus. This strain is capable of high salt tolerance and the secretion of pectinase, which makes it useful in applications such as food processing, waste management, and other industrial uses requiring pectin degradation.

1 year ago

Synthetic Biology

Exoid sea source bacteria secreting xylanase and application thereof.

The invention discloses a kind of sea source bacteria secreting xylanase and its application, and relates to the field of microbial technology, and the invention discovers a new microbial strain, and the bacteria are identified and confirmed to belong to the genus sea source bacteria, named as sea source bacteria MYHB-202307XyL (Aliidiomarina sp. MYHB-202307 XyL). Experiments prove that the strain has the capability of resisting high salt and secreting xylanase.

1 year ago

Synthetic Biology

LATEST HUB PAPER

Tuning Ultrasensitivity in Genetic Logic Gates Using Antisense RNA Feedback

The study introduces antisense RNA (asRNA)-mediated sequestration as a novel mechanism to improve inverting genetic logic gates by co-expressing asRNAs with mRNAs to enhance repression through additional feedback, thereby steepening dose–response curves, reducing OFF-state leakage, and enabling tunable logic transitions for constructing robust combinational circuits; results: improved gate sharpness and reduced leakage.

3 months ago Synthetic Biology

Automated Construction of a Yeast-Based Multigene Library via Homologous Recombination in a Biofoundry Workflow

This study presents an automated one-step multigene assembly method that leverages optimized in vivo homologous recombination within a shuttle vector to efficiently construct expression-tunable multigene libraries, with the process miniaturized for high-throughput applications, successfully enabling rapid and parallel gene assembly in a biofoundry setting.

3 months ago Synthetic Biology

Array Assembler Provides Greatly Simplified crRNA Array Design for CRISPR Cas12 and Cas13 Variants

This study introduces the Array Assembler, a user-friendly computational tool that streamlines the design of oligonucleotides for assembling large crRNA arrays from user-defined spacer sequences, addressing the complexity and error risks in multitarget CRISPR experiments and enabling rapid, reliable construction of crRNA arrays for diverse genomic perturbation applications.

3 months ago Synthetic Biology

Engineered Bacteria Convert a 3-Bit Binary Code to a 3-Bit Gray Code by Multicellular Artificial-Neural-Network-Type Architecture

This study demonstrates a single-layer artificial neural network constructed from five genetically engineered E. coli populations that converts 3-bit binary chemical inputs into Gray code outputs via expression of fluorescent proteins, showcasing a novel approach to neuromorphic computing with living cells and advancing biocomputer technology and synthetic biology applications.

3 months ago Synthetic Biology

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