ACCELERATING. SYNTHETIC BIOLOGY. ADVANCEMENT

Denmark-based Cellugy secured $9.25M in EU LIFE Programme funding to scale production of EcoFLEXY, a cellulose-based rheology modifier replacing fossil-based carbomers and aiming to eliminate up to 1,289 tons of microplastics annually by 2034.

RIKEN Center for Sustainable Resource Science (CSRS) have successfully used insects as mini molecule-making factories, marking a breakthrough in chemical engineering. Referred to as “in-insect synthesis,” this technique offers a new way to create and modify complex molecules, which will generate new opportunities for the discovery, development, and application of non-natural molecules, such as nanocarbons.

Synthetic biologists design and build new segments of DNA that can then be inserted into living organisms to work like circuits in electronics or a computer. Just as a switch is used to turn a lightbulb on or off in an electric circuit, the team’s “toggle” turns genes on and off when an external signal is applied.

ArtemisAI combines constraint-based modeling with machine learning. It creates a hybrid system that provides predictive and interpretable insights. Even with limited data, it helps make faster, smarter decisions in microbial engineering and media optimization.

The invention presents a polyphosphokinase mutant designed to improve the efficiency of the ATP regeneration system. By introducing mutations Y286Stop or L290Stop in the wild-type polyphosphokinase, the mutant exhibits higher activity. When used in a genetically engineered Escherichia coli strain, this mutant catalyzes the synthesis of NMN (nicotinamide mononucleotide) from D-ribose, ATP, and nicotinamide, achieving a high yield of 25.2 g/L in 3 hours, demonstrating significant industrial potential for large-scale NMN production.

The invention provides a method for producing polyhydroxyalkanoate (PHA) via semi-continuous fermentation using Halomonas as a base strain, with the overexpression of the cell division protein gene ftsZ. This approach addresses the issues of reduced splitting activity and lower yield due to metabolic disturbances during long continuous fermentation, achieving high PHA yields in practical applications, and offering strong potential for industrial scalability.

The invention discloses a pectinase-producing strain, identified as Microvesicles MYHB-202306PeC, belonging to the Microvesicles genus. This strain is capable of high salt tolerance and the secretion of pectinase, which makes it useful in applications such as food processing, waste management, and other industrial uses requiring pectin degradation.

The invention discloses a kind of sea source bacteria secreting xylanase and its application, and relates to the field of microbial technology, and the invention discovers a new microbial strain, and the bacteria are identified and confirmed to belong to the genus sea source bacteria, named as sea source bacteria MYHB-202307XyL (Aliidiomarina sp. MYHB-202307 XyL). Experiments prove that the strain has the capability of resisting high salt and secreting xylanase.

The study introduces antisense RNA (asRNA)-mediated sequestration as a novel mechanism to improve inverting genetic logic gates by co-expressing asRNAs with mRNAs to enhance repression through additional feedback, thereby steepening dose–response curves, reducing OFF-state leakage, and enabling tunable logic transitions for constructing robust combinational circuits; results: improved gate sharpness and reduced leakage.

This study presents an automated one-step multigene assembly method that leverages optimized in vivo homologous recombination within a shuttle vector to efficiently construct expression-tunable multigene libraries, with the process miniaturized for high-throughput applications, successfully enabling rapid and parallel gene assembly in a biofoundry setting.

This study introduces the Array Assembler, a user-friendly computational tool that streamlines the design of oligonucleotides for assembling large crRNA arrays from user-defined spacer sequences, addressing the complexity and error risks in multitarget CRISPR experiments and enabling rapid, reliable construction of crRNA arrays for diverse genomic perturbation applications.

This study demonstrates a single-layer artificial neural network constructed from five genetically engineered E. coli populations that converts 3-bit binary chemical inputs into Gray code outputs via expression of fluorescent proteins, showcasing a novel approach to neuromorphic computing with living cells and advancing biocomputer technology and synthetic biology applications.